In addition, GF mice exhibited higher adrenocorticotropic hormone (ACTH) and corticosterone elevation in response to restraint stimulus than SPF mice did (Sudo et al. In patients with chronic fatigue syndrome, Rao et al. 2015). At the same time fecal Lactobacillus and Bifidobacteria increased after 2-month L. casei intervention (Rao et al. La cepa PS128 de Lactobacillus plantarum, por ejemplo, es conocida por aumentar la dopamina y la serotonina y disminuir los comportamientos similares a la depresión en ratones. Lactobacillus plantarum strain PS128, for example, is known to increase dopamine and serotonin and decrease depression-like behaviors in mice. 2014). Significant difference between control treated group at *, Help us to further improve by taking part in this short 5 minute survey, Distribution of Free and Bound Phenolic Compounds in Buckwheat Milling Fractions, The Introduction of Thousands of Tonnes of Glyphosate in the food Chain—An Evaluation of Glyphosate Tolerant Soybeans, http://creativecommons.org/licenses/by/4.0/, RBC distribution width coefficient of variation (RDW-CV), RBC distribution width standard deviation (RDW-SD), To assess the potential mutagenic effect using the bacterial strain, To assess the potential mutagenic effect in vitro, To assess the potential mutagenic effect in vivo, To exam the possible health hazards likely to arise from repeated exposure of PS128, To test the possibility of resistance to antibiotics, Detection of amino acid decarboxylase genes, To detect the possible biogenic amine-producing potential. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific brain regions. In addition, supplementation of probiotics can improve mood status in community and clinical participants. HAMD-17 < 14 Exclusion Criteria: 1. daily ingestion of Lactobacillus plantarum PS128 capsules, daily ingestion of 60 billion colony forming unit (CFU) of Lactobacillus plantarum PS128 (30 billion CFU/capsule). 2010; Howren et al. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Liao, J.F. The PGIC consists of one item taken from the clinical global impression and adapted to the patient. 2012). Oral administration of Lactobacillus plantarum K68 ameliorates DSS-induced ulcerative colitis in BALB/c mice via the anti-inflammatory and immunomodulatory activities. those of the individual authors and contributors and not of the publisher and the editor(s). Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice. These changes were comparable to those observed in the citalopram group, suggesting that some probiotic benefits are similar to antidepressant effects (Desbonnet et al. Adult male C57BL/6 mice given HFD microbiota had significant and selective disruptions in exploratory, cognitive, and stereotypical behavior compared with mice with control diet microbiota. Symptoms of PD will be clinically evaluated before and after the treatment, and the results will be compared. Liu, Y.W. 2015). 2009), but only a subgroup of patients with MDD has a higher level of inflammation. ; Li, C.H. One possible mechanism contributing to systemic inflammation in patients with MDD is bacterial translocation due to increased gut permeability (leaky gut). Compared to specific pathogen free (SPF) mice with a normal gut microbiota, GF mice display increased motor activity and reduced anxiety behavior. The differences between means were tested for statistical significance using a one-way ANOVA followed by a Dunnett’s multiple comparison test.

; Cheng, W.S. 2015).

We hypothesize that PS128 can (1) change the composition of gut microbiota; (2) improve gut permeability, which is measured by fecal zonulin level, and inflammation, which is measured by fecal calprotectin level; (3) reduce the translocation of pathogen into circulation system, which will be demonstrated by reduced TLR expression, (4) reduce IL-6 and TNF-alpha, and hs-CRP, and increase IL-10 level. The biopsy sections of heart, lung, liver, spleen, kidney, adrenal gland, and gonads were fixed with 4% formaldehyde in phosphate-buffered saline (PBS) at pH 7.4. Taipei Medical University WanFang Hospital, Investigator Title: ; de Las Rivas, B.; Marcobal, A.; Munoz, R. Molecular methods for the detection of biogenic amine-producing bacteria on foods. 2009). The statements, opinions and data contained in the journal, © 1996-2020 MDPI (Basel, Switzerland) unless otherwise stated. This is a two-phase study. The statements, opinions and data contained in the journals are solely 2010). 2010).

2016) and 45% in patients with treatment-resistant depression (Raison et al. 1. Lactobacillus plantarum PS128 TM was isolated from spontaneously fermented mustard greens in Taiwan [].Daily intake of this bacteria increased locomotor activity and dopamine and serotonin levels and reduced anxiety-like behavior in germ-free mice [].Serum analysis results showed reduced levels of corticosterone and inflammatory cytokines as well as increased levels of anti-inflammatory cytokines. 2011). 2016). 2015). These authors equally contributed to this work. Lactobacillus plantarum is generally recognized as safe (GRAS). ; Jun, D.W.; Lee, H.L.

Administration of Lactobacillus farciminis could alleviate intestinal permeability and inflammation in partial restraint rats (Ait-Belgnaoui et al. It can alleviate depressive-like behavior reduce inflammation level in maternal separation mice. Zareie, M.; Johnson-Henry, K.; Jury, J.; Yang, P.C. Liu, Y.W. In MS model, however, PS128 significantly reduced depression-like, but not anxiety-like behaviors. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03566589. 2004).

; Su, Y.W. ; Tsai, H.P. ; Wu, C.C. 2013). Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial. Choosing to participate in a study is an important personal decision. Comorbid with schizophrenia, bipolar disorder, or other substance use (except tobacco) disorder.

Several studies have shown that manipulation of gut microbiota can affect the presentation of host's psychophysiology. Microbes leaking from gut activate the MAMPs and pattern-recognition receptors, such as Toll-like receptors (TLRs). Higher values represent a worse outcome. The authors declare that there are no conflict of interest. Psychotropics including antidepressants, antipsychotics and hypnotics have been kept unchanged for at least 3 months 4. hs-CRP > 3 mg/L 5. ; Cheng, T.H. Information provided by (Responsible Party): The purpose of this study is to examine the short term effects (12 Weeks) of Lactobacillus plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Change in Unified Parkinson's Disease Rating Scale (UPDRS) Score From Baseline to Change in Unified Parkinson's Disease Rating Scale (UPDRS) (Part III) Motor Score From Baseline to Week 12 Assessed On Medication [ Time Frame: Baseline to Week 12 ], Change in Nonmotor Symptoms: 30-item Screening Questionnaire (NMS-Quest) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ], Change in Patient Global Impression of Change (PGIC) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ], Diagnosed as a patient with Parkinson's disease of modified Hoehn and Yahr Stage between 1 and 2.5 as rated during an "on" period, Patients on antibiotics within the preceding one month, Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks, Have current or history of inflammatory bowel disease, Have undergone surgery of liver, bladder, or gastrointestinal tract, Patients with comorbid dementia (Mini-Mental State Examination score ≤ 26) or major depression (The Beck Depression Inventory-II score ≥ 29), Patients receiving artificial enteral or intravenous nutrition. Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells. ; Wu, Y.C. The minimum total score possible is 0 and the maximum total score possible is 30. The funders had no role in study design, data collection, or analysis.
One recent metaanalysis showed that childhood trauma contributes to a pro-inflammatory state in adulthood (Baumeister et al. 2. having active suicidal or homicidal ideation 3. known allergy to probiotics 4. comorbid with hypertension, diabetes mellitus, irritable bowel syndrome, inflammatory bowl disease, liver cirrhosis, or autoimmune diseases 5. known active bacterial, fungal, or viral infections in one month. ; et al. ; Chung, W.S. Meta-analysis has shown that patients with depression have higher levels of inflammatory markers, such as C-Reactive Protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF)-alpha (Dowlati et al. Gross necropsy was performed for analyzing external and internal features macroscopically [. All surgeries were executed under isoflurane anesthesia to minimize suffering. found that administration of Lactobacillus casei for 2 months could improve BAI, but not BDI, compared to placebo. 2011). 2002). ; Sohn, W.; Lee, O.Y. Get the latest research information from NIH: You have reached the maximum number of saved studies (100).


2016; Rogers et al. PS128 can reduce IL-6 levels and increased IL-10 level, which accompanied with improved depression-like behavior, in MS mice (Liu YW et al. Room temperature was maintained at 22.0 ± 2.0 °C with a relative humidity between 39 and 43%. Comorbid with schizophrenia, bipolar disorder, or other substance use (except tobacco) disorder. It has been one of the leading causes of global burden of disease, especially in the middle-age groups (GBD Lancet 2016; 388:1603-58). 474: Mammalian Erythrocyte Micronucleus Test, Data are expressed as mean ± S.D.

2. having active suicidal or homicidal ideation 3. known allergy to probiotics 4. comorbid with hypertension, diabetes mellitus, irritable bowel syndrome, inflammatory bowl disease, liver cirrhosis, or autoimmune diseases 5. known active bacterial, fungal, or viral infections in one month. ; Wang, S.; Tsai, Y.C. 1.6 Rationale of current study PS128 was found in traditional fermented food, fu-tsai, by our co-PI (Tsai YC) and its genome architecture has been finished and indicated its potential immunomodulatory effect. HFD also increased anxiety-like behavior (Sharma et al. 6. use of antibiotics, steroid, immunosuppressants, probiotics, or synbiotics in the month before collecting blood and fecal samples 7. pregnant or lactating women 8. who obviously change dietary pattern or in diet within previous two months, Investigator Affiliation: Probiotics may affect gut permeability. ; Lee, W.T. Intervention Name: Guidance on the assessment of bacterial susceptibility to antimicrobials of human and veterinary importance.

2012). Lactobacillus plantarum PS128, Criteria: Animals were fasted overnight (16–18 h) and placed in an induction chamber with 2% isoflurane in 100% oxygen at a constant flow of 1.0 L/min using a Matrx VIP 3000 vaporizer (Midmark, Dayton, OH, USA) for general anesthesia at the end of the 28 day toxicity test. ; Chiang, Y.C. ; Huang, W.K. Metaanalyses have shown that patients with MDD have elevated serum inflammatory cytokins (Dowlati et al. Animal testing criteria mandated that a loss over 20% of body weight related to the original weight was considered a humane endpoint in this study. ; Wu, C.C. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals.