Canadian biotechnology company Quadra Logic Technologies (now QLT Inc.), co-founded by Julia Levy, develops and commercializes the photodynamic (light-sensitive) drug Visudyne™. Heparin finds immediate and widespread clinical applications. Dr. Julio Montaner already knew the drug cocktail known as HAART (highly active antiretroviral therapy) curbed HIV symptoms. Perseverance is also a shared characteristic. Biomedical engineer Milos Popovic is generating a great deal of buzz.
“When I finally went to see her,” says the Oakville, Ont., resident, 39 years old at the time, “she said, ‘Oh, no, it’s nothing. “This has the potential to spare large numbers of women the health risks and complications associated with chemotherapy,” says Alain Nepveu, a McGill molecular biologist.
Image courtesy of the National Institute on Aging/National Institutes of Health. But after a cell is stressed, some of its proteins clump together and don’t work properly.
Two Canadian doctors later made major contributions to developments in anesthesiology.
Kalow discovers genetic variations of plasma cholinesterase, which can cause potentially life-threatening reactions to anesthesia (pain-blocking drugs) in certain people and writes the first textbook on Pharmacogenetics. At 17 months she received her first functional prosthesis, and at ten was one of the first children in Ottawa to be fitted with a myoelectric arm – a limb that translates electrical impulses from skin contact into movement. Medical professionals share her frustration. Gene by gene, they built an understanding of how more than 100 different immune system genes worked. About 3,000 cobalt-60 therapy units, most of them built in Canada, were distributed around the world and used to treat millions of cancer patients. More Canadian medical discoveries like this can have a real impact on the future of the disease. Thanks to Dr. Scriver's studies, Vitamin D is added to all Canadian milk. Researchers are also looking into using stress proteins, also called heat shock proteins because they were initially discovered following heat stress, to protect against brain damage that follows heart attack and stroke. What if there was a way to conceal mismatched blood from the immune system? In 1959, using transistor technology, the first implantable pacemaker was developed in Sweden. But Trudeau has shown these neurons also secrete glutamate. Drugs using this approach are now being used to treat some kinds of leukemia. Pablum, a vitamin-enriched (A,B,D,E) cereal for infants, is developed by pediatricians Frederick Tisdall, Theodore Drake and Alan Brown at the Hospital for Sick Children in Toronto. Canadian inventions and discoveries are objects, processes or techniques invented, innovated or discovered, which owe their existence either partially or entirely to a person born in Canada, a citizen of Canada or a company or organization based in Canada. Chci vědět více. A practical application is likely many years away, but Valley can’t help but get excited. Given the fact there is a pool of researchers in Canada, and there is so much promise in cell therapy, Nagy expects quick progress on research. To review this information or withdraw your consent please consult the. He has since led a team that has produced 20 patented molecules for use in drug development. “They are essentially capable of communicating using more than one type of neurotransmitter,” says Louis-Eric Trudeau of the University of Montreal’s Department of Pharmacology, who made the discovery as part of a team that included scientists from McGill University and other international research centres.
Although degenerative neurological diseases like Alzheimer’s, Parkinson’s and ALS (amyotrophic lateral sclerosis) have different effects, one feature they have in common is the formation of clumps of proteins in the brain. “It’s still early days” for discoveries and innovations in diagnosis and therapy, he says. Patients have less pain and a shorter recovery period after the procedure. The procedure involves taking healthy fecal matter from a donor, mixing it with a saline solution, then introducing it into the patient’s digestive tract, where the good bacteria can re-establish itself. Canadian freeze-dried smallpox vaccine developed by Connaught Laboratories serves as the international standard for the global smallpox eradication program.
Nuclear medicine has come a long way; today there are more than 100 applications for treatment and diagnosis. Alfonso Abizaid, in collaboration with international researchers, found that when certain receptors in the hypothalamus are stimulated by nicotine, there’s a boost to the metabolism and hunger is ignored. But when the data started rolling in, Montaner – today the director of the BC Centre for Excellence in HIV/AIDS – was surprised: Transmission rates in British Columbia were dropping. Canadian researchers have continued to perfect methods for delivering maximum dosages to tumours, while minimizing damage to healthy tissue.
For Smith, whose cancer treatment is ongoing, this would be good news. Dr. Lorne Tyrrell, at the University of Alberta, performs key clinical trials using a Pekin duck as a model that demonstrates the antiviral activity of 3TC (Lamivudine) against the Hepatitis B virus (HBV). The equipment resembled a giant science fiction ray gun weighing 31⁄2 tons. Scientists are at work on a weight-loss drug that mimics the ingredient in nicotine that binds with these specific receptors.
The first was the discovery, in the 1840s, of anesthetic, which rendered surgery painless. “The technique is now an integrated approach in fields of molecular biology and molecular genetics.”This technique was used by a biotechnology company to alter the DNA structure of a strain of yeast to form cells that excrete insulin for treatment of diabetes. Fighting Paralysis. Yet it was during those post-mortems that Papadopoulos discovered what he was looking for.
Canadian Invention 3: First Electric Light Bulb, 1874 Henry Woodward, a medical student from Toronto, patented the first incandescent lamp with an electric light bulb after testing it 87 times. Canada invented a couple medically important inventions. “We have a robust research community in Canada,” says Brown, who expects many more stress researchers will follow in Selye’s groundbreaking footsteps. For Montaner, this gives hope to the 33 million people currently struggling with HIV worldwide. By blocking an enzyme known as “UROD,” researchers Emma Ito and Dr. Fei-Fei Liu discovered that the damage to cancer cells can be amplified.
The world's first commercial therapeutic application of nanotechnology is invented by Dr. Robert Burrell at the University of Alberta.